The CASCADE Study is a clinical research study that will look at a potential new treatment for low back pain due to degenerative changes of a spinal disc.
The investigational product is made from a certain type of adult stem cell. It is given as a one-time injection, either alone or in combination with a carrier material. Eligible patients will be randomly assigned (like flipping a coin) to one of three groups: stem cells alone, stem cells mixed with a carrier material, or saline placebo (which looks like the investigational product but contains no active ingredient). There is a 2 out of 3 chance of being assigned to one of the two groups that will receive the stem cells.